Sandrena® (estradiol) gel

Sandrena (estradiol hemihydrate) is a transdermal oestrogen gel used for the treatment of oestrogen deficiency symptoms in postmenopausal women. It provides flexible dosing options and convenient once‑daily application.

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Clinical information

Indication Dosing & Administration Clinical Evidence Composition Safety PBS Information Patient Support (HCP Use Only)

Patient support & resources

Product Presentations Resources

Women deserve a choice of MHT

Sandrena® transdermal gel provides body-identical estradiol in a high-concentration, low-volume formulation designed to support individualised dosing for menopausal symptom management.

This information is intended for healthcare professionals to support prescribing decisions and patient counselling.

Reference: Sandrena Product Information (PI), 24 February 2025.

Key Features

Transdermal estradiol gel for the treatment of oestrogen deficiency symptoms in postmenopausal women.
Body‑identical estradiol (estradiol hemihydrate).
Flexible dosing options to support individualised menopausal symptom management.

High‑concentration, low‑volume formulation for convenient once‑daily application.
Minimal skin residue and fast‑drying gel.
Suitable for women with an intact uterus when used with a progestogen.

Key Product Information

PBS Information

PBS listing	Sandrena 0.5 g and 1.0 g sachets are PBS listed.
Restriction	Listed for the treatment of menopausal symptoms in eligible patients as per PBS criteria.
Strengths listed	0.5 g sachet (0.5 mg estradiol) and 1.0 g sachet (1 mg estradiol).
Notes	Refer to the PBS Schedule for full details.

Product Presentations

Formulation	Transdermal estradiol gel.
Sachet strengths	0.5 g sachet (0.5 mg estradiol) 1.0 g sachet (1 mg estradiol)
Pack sizes	Available in packs of 28 single‑dose sachets.
Storage	Store below 25°C.